Meet the cast of The Dropout and their real-life counterparts

Ahead of the series initially debuting, Seyfried previously revealed that she never met with Holmes before playing her, telling Good Morning America: "I was never too concerned with us being on the wrong path because of all the research and [show creator] Liz Meriwether at the helm.

"This is our version of the story, and then real life is happening. And you’re like – you want to be involved but you don’t want to be too involved because you want to be able to serve the story."

She added: "Being able to absorb the footage and mimic somebody and try to embody somebody that actually... there's a template out there, is very exciting. I hate to say that because it’s a real person with real consequences and a real life – and I wish her well – I just, as an actor, very specifically, it was thrilling."

Seyfried went on to win a number of awards for her performance, including an Emmy and a Golden Globe. However, she wasn't the only star whose performance in the series was critically acclaimed.

The likes of Naveen Andrews (Lost) and includes supporting roles for Stephen Fry (Everything Now), Dylan Minnette (Scream) and Laurie Metcalf (Hacks) all received plaudits for their work in the show.

Read on for everything you need to know about The Dropout cast, including side-by-side comparisons with the real people they are portraying.

The Dropout cast: Actors vs real-life counterparts

Amanda Seyfried plays Elizabeth Holmes

Who is Elizabeth Holmes? Elizabeth Holmes was the founder and CEO of now-defunct health technology company Theranos. She dropped out of California's prestigious Stanford University to pursue development of a revolutionary device that could theoretically run dozens of health tests on a single drop of blood. A nice idea in concept, but one that was fundamentally unworkable with today's technology. Nevertheless, she continued securing investment from some of the world's richest people under false pretences, until a whistle-blower exposed that her company was not what it appeared to be.

Where have I seen Amanda Seyfried before? Seyfried first rose to fame in the cast of hit teen comedy Mean Girls, where she played the dim-witted Karen Smith. She followed that up with a main role on HBO drama Big Love, before returning to the big screen in 2008 for musical phenomenon Mamma Mia!, where she starred opposite Hollywood royalty Meryl Streep. Most recently, she earned acclaim for her performance in David Fincher's Mank, which earned her an Academy Award nomination for Best Supporting Actress.

Laurie Metcalf plays Dr Phyllis Gardner

Who is Dr Phyllis Gardner? Dr Gardner is a Professor of Medicine at Stanford University, who crossed paths with Holmes during her brief time studying there and became an early sceptic of her scientific know-how. The aspiring inventor booked a meeting with Dr Gardner to pitch her first big idea – a patch that would detect infections in the human body and administer antibiotics as required – which the esteemed medical expert quickly dismissed as impossible. She was right.

Where have I seen Laurie Metcalf before? Metcalf has appeared in a number of popular American television shows, including Roseanne and its recent sequel The Conners, Desperate Housewives and The Big Bang Theory. On the big screen, she is known for roles in Uncle Buck, Scream 2, Lady Bird and the Toy Story franchise, where she provides the voice of Andy's mother, Mrs Davis.

Naveen Andrews plays Sunny Balwani

Who is Sunny Balwani? Sunny Balwani served as COO at Theranos for several years, working closely with Holmes during that time. What investors didn't know is that they also had a romantic relationship outside of work, which came to an end around the same time as the company's very public implosion. Balwani is due to stand trial on fraud charges later this year.

Where have I seen Naveen Andrews before? Andrews will be a familiar face to fans of science fiction, owing to his past roles on mystery drama Lost and Netflix's Sense8. He also earned acclaim for his role in 1996 awards contender The English Patient.

Stephen Fry plays Dr Ian Gibbons

Who is Dr Ian Gibbons? Dr Ian Gibbons was a biochemist who served as chief scientist at Theranos for a number of years, endeavouring to get the ambitious machine envisioned by Holmes up and running. His mental health began to take a turn for the worse when he was fired by Theranos, before being rehired in a reduced role, and later being subpoenaed to testify in a patent lawsuit against the company. He died of liver failure in 2013, days after attempting to take his own life.

Where have I seen Stephen Fry before? Fry rose to prominence through his comedy work, appearing in the cast of classic BBC sitcom Blackadder and later forming a double act with Hugh Laurie. On the big screen, his most notable projects include Gosford Park, V for Vendetta and The Hobbit trilogy. More recently, he played a fictional politician in Russell T Davies' acclaimed AIDS drama It's A Sin.

Sam Waterston plays George Shultz

Who is George Shultz? George Shultz is the former United States Secretary of State, who served under President Ronald Reagan in the 1980s, and a very wealthy businessman. He is approached by Elizabeth Holmes in 2011 and soon becomes one of the strongest advocates for Theranos, but his grandson fears he is being taken advantage of.

Where have I seen Sam Waterston before? Waterston has been acting since the 1960s and has a long list of credits to his name. His recent projects include police procedural Law & Order, HBO drama The Newsroom and Netflix comedy Grace & Frankie.

Dylan Minnette plays Tyler Shultz

Who is Tyler Shultz? Tyler Shultz is grandson to George, who gets him an internship at Theranos shortly after his graduation from Stanford University. While he is initially thrilled to be working for a lauded pioneer like Elizabeth Holmes, he soon realises things aren't as they should be within her company. However, speaking out won't be easy with the looming threat of devastating legal action and his own family smitten with the CEO – even hosting her 30th birthday party.

Where have I seen Dylan Minnette before? Minnette will be familiar to avid Netflix bingers as Clay Jensen on the hard-hitting teen drama 13 Reasons Why. He is also known for Denis Villeneuve drama Prisoners and a number of horror flicks, including Let Me In, Goosebumps, Don't Breathe and 2022's Scream reboot.

Kate Burton plays Rochelle Gibbons

Who is Rochelle Gibbons? Rochelle Gibbons was married to Dr Ian Gibbons for almost 40 years and blames Theranos for his tragic death.

Where have I seen Kate Burton before? Burton is best known for her roles in US dramas Grey's Anatomy and Scandal, both of which were created by Shonda Rhimes. More recently, she collaborated with the prolific television producer once more for Netflix miniseries Inventing Anna, another dramatisation of a true fraud story.

Michaela Watkins plays Linda Tanner

Who is Linda Tanner? Linda Tanner is an in-house lawyer at Theranos, who embraces the challenge of squashing the company's detractors. While Tanner is one of the few fictional characters in the show, Watkins told RadioTimes.com her performance was inspired by a moment from HBO's Elizabeth Holmes documentary The Inventor.

"I think it was one of those things in the bullpen where everybody was celebrating the moment that the FDA approved one aspect of their testing capabilities," recalled Watkins. "And they were playing Pump Up the Volume and I saw this woman just sort of dancing like she was part of the cult, like drinking the Kool Aid. And I thought that's who she is: she's someone who is so excited to be on the winning team."

Where have I seen Michaela Watkins before? Watkins has worked on several comedic projects, including Saturday Night Live, Casual, Search Party and New Girl, the last of which was created by The Dropout showrunner Elizabeth Meriwether.

Anne Archer plays Charlotte Shultz

Who is Charlotte Shultz? Charlotte Shultz was George's second wife, with the pair being married in 1997. Previously, she was a wealthy socialite and philanthropist.

Where have I seen Anne Archer before? Archer is probably best known for her acclaimed performance in 1987 thriller Fatal Attraction, which earned her nominations at the Academy Awards and the BAFTAs, among others. She is also known for playing Barbara Reynolds in hit US comedy It's Always Sunny in Philadelphia.

Camryn Mi-Young Kim plays Erika Cheung

Who is Erika Cheung? Erika is another Theranos employee hired fresh out of university, who became another key figure in exposing the company's irresponsible practices. The stakes were particularly high for her, as she came from an underprivileged background and so could not rely on family wealth if the legal team came after her.

Where have I seen Camryn Mi-Young Kim before? This is the debut television role for Mi-Young Kim.

Ebon Moss-Bachrach plays John Carreyrou

Who is John Carreyrou? John is an investigative reporter for the Wall Street Journal, who receives a tip-off about the dodgy procedures going on at Theranos and pursues the dangerous story.

What else has Ebon Moss-Bachrach been in? Moss-Bachrach is best known for his roles in HBO comedy-drama Girls, action-packed Marvel series The Punisher and, of course, kitchen comedy-drama The Bear.

Utkarsh Ambudkar plays Rakesh Madhava

Who is Rakesh Madhava? Rakesh was one of the first employees to be hired by Theranos and learned the hard way that their technology was far from what it was said to be.

Where have I seen Utkarsh Ambudkar before? Ambudkar had a banner year in 2021, bagging a lead role in the US adaptation of Ghosts alongside appearances in hit movies Free Guy and Tick, Tick... BOOM!. His earlier work includes Pitch Perfect and The Mindy Project.

James Hiroyuki Liao plays Edmond Ku

Who is Edmond Ku? Edmond is another of the early employees at Theranos, who is put under immense pressure to get their blood-testing technology operational.

Where have I seen James Hiroyuki Liao before? Hiroyuki Liao is known for roles in US dramas Prison Break, Unforgettable and HBO's Barry. Last year, he appeared in fantasy fare Cowboy Bebop and Snake Eyes, while he also has a motion capture role in Playstation video game Ghosts of Tsushima.

Alan Ruck plays Jay Rosen

Who is Jay Rosen? Jay Rosen is a senior executive at American pharmacy chain Walgreens, who is keen to partner with Theranos on their retail expansion.

Speaking of his character, Ruck told RadioTimes.com: "He wanted to make one big splash before he hung up his spurs and I think that he met this young woman, found out about her and… he just wanted to believe it – I think almost as much as Elizabeth wanted to believe it.

"Because he was going to be a hero [and] he was going to get a hell of a retirement package out of that deal," continued Ruck. "He just kind of sold out… and it's a shame because he's not a dumb guy. He's a bright fellow, but he disregarded science, which as we know is a mistake."

Where have I seen Alan Ruck before? Ruck appeared in several iconic movies in the '80s and '90s including Ferris Bueller's Day Off, Speed and Twister. More recently, he has acquired a new generation of fans as part of the Succession cast, where he played Connor Roy.

William H Macy plays Richard Fuisz

Who is Richard Fuisz? Richard Fuisz is an inventor and entrepreneur who was a neighbour of the Holmes family during Elizabeth's childhood and later became locked in a legal dispute with her company, Theranos.

Where have I seen William H Macy before? Macy is best known for starring in the American version of comedy-drama Shameless, which ran for an impressive 11 seasons on US broadcaster Showtime. Previously, he had appeared in medical drama ER. On the big screen, he is known for awards contenders Fargo and Room (starring Captain Marvel's Brie Larson), as well as blockbuster Jurassic Park III.

Nicky Endres plays Ana Arriola

Who is Ana Arriola? Ana is a prolific product designer, who Holmes approaches to transform Theranos products after being impressed by their work at Apple.

Where have I seen Nicky Endres before? Endres has previously appeared in Netflix sitcom One Day At a Time.

Elizabeth Marvel plays Noel Holmes

Who is Noel Holmes? Noel Holmes is Elizabeth's mother and a supportive figure in her life.

Where have I seen Elizabeth Marvel before? Marvel has appeared in a number of acclaimed television shows, including House of Cards, Homeland, Fargo and Unbelievable. On the big screen, she has a similarly strong track record, with lauded projects including Burn After Reading, True Grit, Lincoln, A Most Violent Year and Netflix drama The Meyerowitz Stories.

LisaGay Hamilton plays Judith Baker

Who is Judith Baker? Judith Baker is a senior editor at the Wall Street Journal.

Where have I seen LisaGay Hamilton before? Hamilton is best known for her television roles on legal drama The Practice and political thriller House of Cards. Her film projects include 12 Monkeys, Vice and biopic Lovelace, the last of which also starred Amanda Seyfried.

The Dropout is available to stream on BBC iPlayer and on Disney Plus, and is airing on BBC One from 10:40pm on Tuesday 19th March 2024 .You can sign up to Disney Plus for £7.99 a month or £79.90 a year now.

Check out more of our Drama coverage or visit our TV Guide and Streaming Guide to find out what's on.

Try Radio Times magazine today and get 10 issues for only £10 – subscribe now. For more from the biggest stars in TV, listen to The Radio Times Podcast.